Detailed Abstract
[Poster Exhibition]
[P128] The Change of Glucose Metabolism with GLP-1 after Pancreatectomy
Kwangyeol PAIK1, Mikyung KIM2, Jiseon OH1
1HBP Surgery, Yeouido St.Mary's Hospital, The Catholic University of Korea, Korea
2Internal Medicine, Endocrinology, Yeouido St.Mary's Hospital, The Catholic University of Korea, Korea
Introduction : The aims of this study were to investigate the postoperative B-cell function (BCF), insulin resistance and hormonal responses of glucagon-like peptide-1 (GLP-1) after pancreatectomy.
Methods : Oral glucose tolerance tests were performed in 19 patients (11 pancreaticoduodenectomy (PD) and 8 Left sided pancreatectomy (LP)) before and 1 month after operation. The changes in the serum glucose and insulin concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), pancreatic BCF and GLP-1 were analyzed.
Results : The plasma insulin concentrations and BCF were significantly lower after PD. There was improvement of AUCGLP-1 was observed after PD. HOMA-IR after PD showed no change. Whereas all parameters of glucose metabolism and AUCGLP-1 were not changed after LP.
Conclusions : The changes in glucose metabolism and GLP-1 responses were different between PD and LP.
Methods : Oral glucose tolerance tests were performed in 19 patients (11 pancreaticoduodenectomy (PD) and 8 Left sided pancreatectomy (LP)) before and 1 month after operation. The changes in the serum glucose and insulin concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), pancreatic BCF and GLP-1 were analyzed.
Results : The plasma insulin concentrations and BCF were significantly lower after PD. There was improvement of AUCGLP-1 was observed after PD. HOMA-IR after PD showed no change. Whereas all parameters of glucose metabolism and AUCGLP-1 were not changed after LP.
Conclusions : The changes in glucose metabolism and GLP-1 responses were different between PD and LP.
SESSION
Poster Exhibition
Room E 4/6/2019 3:00 PM - 3:50 PM