Introduction : Efficacy and outcomes of laparoscopic resection for panreatic neuroendocrine tumors(PNETs) are well established; specific data for laparoscopic pancreaticoduodenectomy(L-PD) are limited. The purpose of this study to evaluate the clinical and oncologic outcomes after L-PD versus open-PD(O-PD) for PNETs.

Methods : Bewteen January 2006 and December 2017, 151 patients with PNETs underwent O-PD or L-PD at Asan Medical Center. Of these patients, 58 underwent a laparoscopic approach and 93 an open technique. A retrospective study was performed to evaluate clinical and oncologic outcomes of L-PD group compared with O-PD group.

Results : The mean operative time for the L-PD group was longer than fot the O-PD(p=0.001) and the mean duration of the postoperative stays was shorter in L-PD group(p<0.001). Overall complication did not differ significantly between L-PD and O-PD groups(p=0.607). Oncologic outcomes demonstrated no significant differences in resection margin, size of tumor, tumor grading or T/N stages. The number of harvested lymph node in L-PD was lower than those i O-PD(7.1 versus 10.8, p=0.001). Three-year overall survival after PD for PNET was 95.0% in L-PD and 90.0%in O-PD(p=0.074). Three-year disease free survival in L-PD 90.9% compared to 86.9% in O=PD(p=0.235).

Conclusions : L-PD for PNETs in selected patients is feasible and the the advantages of a short recovery and reduced hospital stay. L-PD for PNETs had similar survival compared with O-PD, however the opposing difference in harvested lymph node strengthen a randomized trial to confrim the oncological safety of L-PD for PNETs.