Detailed Abstract
[Poster Exhibition]
[P105] Intraoperative transfusion: A controllable independent prognostic factor of resected pancreatic cancer
Si Youn KIM1, Ho Kyoung HWANG2, 3, Seung Yun NOH2, 3, Woo jung LEE2, 3, Chang Moo KANG* 2, 3, Eun Ju LEE4, Jin Ae LEE4
1Yonsei University College of Medicine, Yonsei University College of Medicine, Korea
2Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Korea
3Pancreatobiliary Cancer Center, Yonsei Cancer Cent
Introduction : The aim of this study is to investigate whether intraoperative transfusion(IOT) is a prognostic factors to predict long-term oncologic outcomes of resected pancreatic cancer.
Methods : Respective analysis was performed on patients who underwent pancreatectomy from June 2004 to December 2014 at Severance Hospital.
Results : Among 305 patients who underwent pancreatectomy, the recurrence and disease-specific survival rates of the patients who received IOT showed significantly poorer survival outcomes compared to those who did not(P = 0.0194, P = 0.0053). And estimated blood loss(EBL) of the patient was one of the most powerful predicting factors for IOT(P<0.0001). In univariate analysis, IOT(HR=1.42[95% CI: 1.05-1.92], P=0.0239), T status(≥2cm, HR=2.09[95% CI: 1.31-3.32], P=0.0020), N status(N1&N2, HR=1.67[95% CI: 1.26-2.2], P=0.0003), and presence of symptoms(HR=1.6[95% CI: 1.1-2.32], P=0.0239) were analyzed to predict tumor recurrence. Also, IOT(HR=1.57[95% CI: 1.14-2.17], P=0.0063), T status(≥2cm, HR=2.36[95% CI: 1.46-3.83], P=0.0005), N status(N1&N2, HR=1.66[95% CI: 1.22-2.24], P=0.0011), and presence of symptoms(HR=1.57[95% CI: 1.05-2.36], P=0.0281) were analyzed to predict disease-specific survival rate in resected pancreatic cancer. Subsequent multivariate analysis showed that T status(HR=1.96[95% CI: 1.21-3.18], P=0.0067), N status(HR=1.68 [95% CI: 1.25-2.27], P=0.0006) and presence of symptoms (HR=1.52[95% CI: 1.03-2.22], P=0.0335) were independent prognostic factors that predicted tumor recurrence. In addition, it showed that IOT(HR=1.76[95% CI: 1.2-2.59], P=0.0042), T status(HR=2.35[95% CI: 1.41-3.91], P=0.0010), N status(HR=1.61[95% CI: 1.17-2.23], P=0.0039) and presence of symptoms(HR=1.58[95% CI: 1.03-2.41], P=0.0359) were independent prognostic factors that predicted disease-specific survival in resected pancreatic cancer.
Conclusions : Intraoperative transfusion (IOT) act as an independent prognostic factor in resected pancreatic cancer. Therefore IOT should be avoided if possible.
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Methods : Respective analysis was performed on patients who underwent pancreatectomy from June 2004 to December 2014 at Severance Hospital.
Results : Among 305 patients who underwent pancreatectomy, the recurrence and disease-specific survival rates of the patients who received IOT showed significantly poorer survival outcomes compared to those who did not(P = 0.0194, P = 0.0053). And estimated blood loss(EBL) of the patient was one of the most powerful predicting factors for IOT(P<0.0001). In univariate analysis, IOT(HR=1.42[95% CI: 1.05-1.92], P=0.0239), T status(≥2cm, HR=2.09[95% CI: 1.31-3.32], P=0.0020), N status(N1&N2, HR=1.67[95% CI: 1.26-2.2], P=0.0003), and presence of symptoms(HR=1.6[95% CI: 1.1-2.32], P=0.0239) were analyzed to predict tumor recurrence. Also, IOT(HR=1.57[95% CI: 1.14-2.17], P=0.0063), T status(≥2cm, HR=2.36[95% CI: 1.46-3.83], P=0.0005), N status(N1&N2, HR=1.66[95% CI: 1.22-2.24], P=0.0011), and presence of symptoms(HR=1.57[95% CI: 1.05-2.36], P=0.0281) were analyzed to predict disease-specific survival rate in resected pancreatic cancer. Subsequent multivariate analysis showed that T status(HR=1.96[95% CI: 1.21-3.18], P=0.0067), N status(HR=1.68 [95% CI: 1.25-2.27], P=0.0006) and presence of symptoms (HR=1.52[95% CI: 1.03-2.22], P=0.0335) were independent prognostic factors that predicted tumor recurrence. In addition, it showed that IOT(HR=1.76[95% CI: 1.2-2.59], P=0.0042), T status(HR=2.35[95% CI: 1.41-3.91], P=0.0010), N status(HR=1.61[95% CI: 1.17-2.23], P=0.0039) and presence of symptoms(HR=1.58[95% CI: 1.03-2.41], P=0.0359) were independent prognostic factors that predicted disease-specific survival in resected pancreatic cancer.
Conclusions : Intraoperative transfusion (IOT) act as an independent prognostic factor in resected pancreatic cancer. Therefore IOT should be avoided if possible.
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SESSION
Poster Exhibition
Room E 4/6/2019 3:00 PM - 3:50 PM