Detailed Abstract
[BP Poster Presentation 3]
[P097] Microsatellite instability is associated with early recurrence in resected pT1 and pT2 ampulla of Vater cancer
Jin Hong LIM1, Ho kyoung WHANG2, Jae Uk JUNG2, Dong Sup YOON1, Woo Jung LEE2, Chang Moo KANG* 2
1Surgery, Department of Surgery, Yonsei University College of Medicine, Gangnam Severance hospital, Korea
2Surgery, Department of Surgery, Yonsei University College of Medicine, Severance hospital, Korea
Introduction : Ampulla of Vater cancer(AoVca) is one of the periampullary cancers with a better prognosis, but recurrence still occurs early in some patients. The aim of this study was to evaluate risk factors of early recurrence after curative resection of AoVca.
Methods : Between January 2005 and December 2012, 123 patients received radical resection for AoVca at Yonsei University Medical Center. 74 patients with T1 or 2 stage AoVca were reviewed and analyzed to assess risk factor of early recurrence.
Results : Among the 74 patients, nineteen patients (25.7%) experienced recurrent disease. Thirteen patients (17.5%) suffered recurrent disease within 12 months (early recurrence). The median follow-up for non-recurrence was 81.3 months, 17.6 months for early recurrence, and 34.4 months for late recurrence. After Multiivariate analysis, lymph node involvement(odds ratio 4.34, P=0.02), microsatellite instability (odds ratio; 8.01, P<0.01) were significant predictors for early recurrence.
Conclusions : Lymph node involvement and microsatellite instability were found to be predictors for early recurrence.
Methods : Between January 2005 and December 2012, 123 patients received radical resection for AoVca at Yonsei University Medical Center. 74 patients with T1 or 2 stage AoVca were reviewed and analyzed to assess risk factor of early recurrence.
Results : Among the 74 patients, nineteen patients (25.7%) experienced recurrent disease. Thirteen patients (17.5%) suffered recurrent disease within 12 months (early recurrence). The median follow-up for non-recurrence was 81.3 months, 17.6 months for early recurrence, and 34.4 months for late recurrence. After Multiivariate analysis, lymph node involvement(odds ratio 4.34, P=0.02), microsatellite instability (odds ratio; 8.01, P<0.01) were significant predictors for early recurrence.
Conclusions : Lymph node involvement and microsatellite instability were found to be predictors for early recurrence.
SESSION
BP Poster Presentation 3
Room E 4/6/2019 3:00 PM - 3:50 PM