Introduction : There are many report about solid organ transplantation recipients appear to have a higher risk of malignant tumor. It caused by suppressed immune system fail to surveillance malignant transformation. De novo malignancy after transplantation is the most common cause of late mortality. The aim of the study is to describe of experiences of de novo malignancy of major liver transplantation in South Korea.

Methods : From March 1988 to March 2018. 1793 Adult liver transplantation were performed in Seoul National University Hospital. We reviewed the causes of death and de novo cancer status of these cases retrospectively

Results : A total of 27 de novo cancers were diagnosed among the 1793 recipients. There are 12 cases in 875 hepatocellular carcinoma (HCC) cases and 15 cases in 918 non-HCC cases. De novo cancer is not main cause of death in initial 5 years period, but after 5 year follow-up, is the main cause of death after liver transplantation. The most frequent cancers developed after liver transplantation was lymphoma (25%), second is gastric cancer (18%). And de novo hepatocellular carcinoma in non-HCC cases were found in 2 cases

Conclusions : Liver transplant recipients were at increased risk for developing de novo cancers. We should check-up cancer surveillance on these patient more strictly