Introduction : Although the role of plasmapheresis in liver failure is not clearly established yet, encouraging reports have addressed its efficacy in the setting of resections for primary liver malignancies, small-for-size syndrome after live donor liver transplantation, and acute liver failure.

Methods : Patient was a 67 year-old male, 162cm, 66kg, visisted our hospital with jaundice. He was diagnosed as hilar cholangiocarcinoma, type IIIa with hypertension, diabetes. Preoperative jaundice was resolved with percutaneous trans-hepatic drainage down to 1.51 mg/dl. Preoperative liver volumetry showed that Right lobe was 1127cc (68.9%) and left lobe was 508cc (31.0%).

Results : Rt. Hemihepatecotmy and CBD resection and R-Y hepaticojejunostomy was performed at 11th September 2017. Operation time was 13hrs 45min, estimated blood loss was 1000cc. In the operation, liver looked cholestatic, two opening of Lt. bile duct were anastmosed to jejunum respectively. Immedicately after operation, his total bilirubin was 6.9 mg/dl and it increased up to 15.5 mg/dl at POD 3.
We decided plasmapheresis for salvage from hepatic failure. Fortunately after one time of plasmapheresis, the bilirubin had started to decrease continuously with one to two mg/dl per day. The patient gradually recovered, and discharged with 0.78 mg/dl of total bilirubin at two week later of the plasmaphresis. On one year follow up evaluation, there is no abnormal liver function and recurrence of cholangiocarcinoma.

Conclusions : The factors were related with were cholestasis with bile duct dilation, diabetes, old age, long operation and blood loss. The use of plasmapheresis to decrease portal hyperperfusion and bilirubin after extensive hepatectomy.