Detailed Abstract
[Poster Exhibition]
[P015] Association between Body Mass Index and Postoperative Morbidity after Liver Resection of Hepatocellular Carcinoma A Multicenter Study of 1,324 Patients
Jiong-Jie YU1, Zhen-Li LI1, Lei LIANG1, Jun HAN1, Hao XING1, Wan-Guang ZHANG2, Xian-Hai MAO3, Yong-Yi ZENG4, Ting-Hao CHEN5, Ya-Hao ZHOU6, Hong WANG7, Timothy M. PAWLIK8, Han WU1, Wan Yee LAU1, 9, Han ZHANG 1, Chao LI1, Feng SHEN1, Tian YANG1
1Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, China
2Department of Hepatic Surgery, Tongji Hospital, Huazhong University of Science and Technology, China
3 Department of Hepatobiliary Sur
Introduction : Mortality following liver resection has decreased dramatically over the last several decades such that some centers report a zero incidence of mortality. Postoperative morbidity, however, remains a major concern. The aim of this study was to investigate the association between preoperative body mass index (BMI) and postoperative morbidity after liver resection for hepatocellular carcinoma (HCC).
Methods : Consecutive patients who underwent curative-intent liver resection for HCC from 2010 to 2016 in seven Chinese centers were enrolled. Patients were divided into three groups according to preoperative BMI: low-BMI (≤18.4 kg/m2), normal-BMI (18.5~24.9 kg/m2) and high-BMI (≥25.0 kg/m2). Baseline patient characteristics, operative variables, postoperative 30-day mortality and morbidity were compared. Univariable and multivariable analyses were performed to identify independent risk factors associated with postoperative morbidity.
Results : Among 1,324 patients, 108 (8.2%), 733 (55.4%), and 483 (36.5%) were low-BMI, normal-BMI, and high-BMI, respectively. There were no differences in postoperative 30-day mortality among patients based on BMI (P=0.199). Postoperative 30-day morbidity was, however, higher in low-BMI and high-BMI patients versus patients with a normal-BMI (33.3% and 32.1% vs. 22.9%, P=0.018 and P<0.001, respectively). On multivariable analysis low-BMI and high-BMI remained independently associated with increased postoperative morbidity (OR:1.713, 95% CI:1.070-2.743, P=0.025, and OR:1.534, 95% CI:1.164-2.021, P=0.002, respectively). Similar results were also noted in the incidence of postoperative 30-day surgical site infection (SSI).
Conclusions : Compared with normal-BMI patients, low-BMI and high-BMI patients had higher postoperative morbidity, as well as a higher incidence of SSI after liver resection for HCC.
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Methods : Consecutive patients who underwent curative-intent liver resection for HCC from 2010 to 2016 in seven Chinese centers were enrolled. Patients were divided into three groups according to preoperative BMI: low-BMI (≤18.4 kg/m2), normal-BMI (18.5~24.9 kg/m2) and high-BMI (≥25.0 kg/m2). Baseline patient characteristics, operative variables, postoperative 30-day mortality and morbidity were compared. Univariable and multivariable analyses were performed to identify independent risk factors associated with postoperative morbidity.
Results : Among 1,324 patients, 108 (8.2%), 733 (55.4%), and 483 (36.5%) were low-BMI, normal-BMI, and high-BMI, respectively. There were no differences in postoperative 30-day mortality among patients based on BMI (P=0.199). Postoperative 30-day morbidity was, however, higher in low-BMI and high-BMI patients versus patients with a normal-BMI (33.3% and 32.1% vs. 22.9%, P=0.018 and P<0.001, respectively). On multivariable analysis low-BMI and high-BMI remained independently associated with increased postoperative morbidity (OR:1.713, 95% CI:1.070-2.743, P=0.025, and OR:1.534, 95% CI:1.164-2.021, P=0.002, respectively). Similar results were also noted in the incidence of postoperative 30-day surgical site infection (SSI).
Conclusions : Compared with normal-BMI patients, low-BMI and high-BMI patients had higher postoperative morbidity, as well as a higher incidence of SSI after liver resection for HCC.
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SESSION
Poster Exhibition
Room E 4/6/2019 3:00 PM - 3:50 PM