Detailed Abstract
[Poster Exhibition]
[P014] Is Liver Resection Justified for Multinodular Hepatocellular Carcinoma in Patients with Cirrhosis? A Multicenter Analysis of 1,066 Patients
Zhen-Li LI1, Xian-Hai MAO2, Ting-Hao CHEN3, Jun-Wu GUO1, Wei-Min GU4, Ya-Hao ZHOU5, Hong WANG6, Wan-Guang ZHANG7, Timothy M. PAWLIK9, Wan Yee LAU1, 10, Lei LIANG1, Feng SHEN1, Tian YANG1
1Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, China
2Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, China
3Department of General Surgery, Ziyang First People’s H
Introduction : The role of liver resection for multinodular (≥ 3 nodules) hepatocellular carcinoma (HCC) remains unclear, especially in patients with severe underlying liver disease. We aim to evaluate short-term and long-term outcomes in cirrhotic patients undergoing liver resection for multinodular HCC.
Methods : From a multicenter database, cirrhotic patients who underwent curative liver resection of HCC were enrolled and divided into two groups: the non-multinodular and multinodular HCC groups. Perioperative mortality and morbidity, and overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups.
Results : Among 1,066 cirrhotic patients, 906 (85.0%) had single- or double-nodular HCC (the non-multinodular group), while 160 (15.0%) had multinodular HCC (the multinodular group). There were no any differences in postoperative 30-day mortality and morbidity between the two groups (1.8% vs. 1.9%, P=0.923, and 36.0% vs. 39.4%, P=0.411, respectively). However, the 5-year OS and RFS rates of the multinodular group were worse than those of the non-multinodular group (34.6% vs. 58.2%, and 24.7% vs. 44.5%, both P<0.001). Multivariable analyses revealed that tumor numbers ≥ 5, total tumor diameter ≥ 8 cm and microvascular invasion were independent risk factors for decreased OS and RFS after resection of multinodular HCC in cirrhotic patients.
Conclusions : Liver resection could be safely performed for multinodular HCC in patients with cirrhosis, with an overall 5-year survival rate of 34.6%. Tumor number ≥ 5, total tumor diameter ≥ 8 cm and microvascular invasion were independently associated with decreased OS and RFS after resection in cirrhotic patients with multinodular HCC.
ons
Methods : From a multicenter database, cirrhotic patients who underwent curative liver resection of HCC were enrolled and divided into two groups: the non-multinodular and multinodular HCC groups. Perioperative mortality and morbidity, and overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups.
Results : Among 1,066 cirrhotic patients, 906 (85.0%) had single- or double-nodular HCC (the non-multinodular group), while 160 (15.0%) had multinodular HCC (the multinodular group). There were no any differences in postoperative 30-day mortality and morbidity between the two groups (1.8% vs. 1.9%, P=0.923, and 36.0% vs. 39.4%, P=0.411, respectively). However, the 5-year OS and RFS rates of the multinodular group were worse than those of the non-multinodular group (34.6% vs. 58.2%, and 24.7% vs. 44.5%, both P<0.001). Multivariable analyses revealed that tumor numbers ≥ 5, total tumor diameter ≥ 8 cm and microvascular invasion were independent risk factors for decreased OS and RFS after resection of multinodular HCC in cirrhotic patients.
Conclusions : Liver resection could be safely performed for multinodular HCC in patients with cirrhosis, with an overall 5-year survival rate of 34.6%. Tumor number ≥ 5, total tumor diameter ≥ 8 cm and microvascular invasion were independently associated with decreased OS and RFS after resection in cirrhotic patients with multinodular HCC.
ons
SESSION
Poster Exhibition
Room E 4/6/2019 3:00 PM - 3:50 PM